The ISB is beautiful in its simplicity. Unfortunately, it's not in a Ford (not counting the F-650 or F-750) and still is packed with emissions crap. I'd like to see Cummins convert it to DOHC and make it all aluminum.
Good to see someone knows that you can get a Ford with a Cummins.
However I don't think the I6 SOHC design is the limiting factor in power. The ISB actually has a 385/1000 rating floating out there, and I'm sure more is possible. However this rating is only offered for emergency and RV use. If anything I think that the ISB might be a bit reigned in in the Ram chassis to keep it from destroying Dodge's parts. (Which it seems to do well at even at this rating.)
I wouldn't be surprised with a wet sleeved aluminum block though. It had been done with the 5.9 in the past, not sure why it isn't there for the 6.7.
And the emissions crap is only going to get worse come 2013.
In the end though, you really can't go wrong with the ISB. It's simple and extremely easy to work with, as are all other Cummins engines. Seriously, go look at a Navistar, Ford, Detroit Diesel, or Volvo engines. The complexity is downright frightening. Not to mention it certainly doesn't have a problem making power, even if it comes with less from the factory. Plus it uses the least emissions equipment out of the bunch.
Of course I might be a bit biased...