Your valvetiming has a lot to do with the amount of compression also. If you are running cams with say less than 220' @ .050 and a short exhaust duration ( like Comp Cams in the catalog ) for a good N/A aspirated combo. You may want to stay around 11:1 for a good safe and sane tune. If you step up to say 235' @ .050" you could easily run 11.5 - 12:1. Remember these engines do not need a lot of exhaust duration like the old pushrod engines did/do. And, the higher the compression the faster a four valve head loses internal exhaust pressure once the valve leaves the seats. If you run a dual pattern cam ( more exhaust duration ) like say a crower cam ( as stated in their catalog ), you could feesible get away with a little more compression. But, you may lose some torque down low and more horsepower upstairs in comparison to a cam set that is either single pattern or dual with a slightly less duration exhaust cam. Another note to consider for cams. Too much valve lift on the four valve heads ( not GT or GT500 heads ) can be hard on the valve springs. Our short installed height ( 1.42" - 1.47" )can cause valve spring over heating and breaking. That is why FRPP chose to raise the retainer on their valves , thus adding more spring material. Lending it to more long term reliability and less heat in the spring.