More info and DETAILS about this please!
Here is some info once you request for the updated flex fuel tune. I got this from Jon II:
"All you need to do to ideally switch between fuel is get the tank down to close to 0 miles to Empty then fill up with the other fuel. The PCM will learn the ethanol content within about 10 mins of driving. It starts happening pretty quickly and may learn quicker, but I'm telling people 10 mins just to be safe. The tune will auto adjust commanded fueling at WOT to take advantage of the octane with more ethanol and it'll advance timing to take advantage also."
Its not every little detail but it gives you an idea.