Desert Eagle 50AE, that way you wont even have to get out of bed if you hear a bump in the dark. Just aim and hope your exterior walls stop it from hitting a neighbor.
I have fired my 50AE inside before. If the round doesn't hit 'em, the shockwave will.
I keep a 357 in the nightstand. Once my tax stamps come in, I'll have a suppressed FNP45C sitting there. I also keep a DP12 nearby.
I'm paranoid.